Synthesis of thiophosphoramidates in water: click chemistry for phosphates.
نویسندگان
چکیده
An aqueous method for the preparation of N,S-dialkyl thiophosphoramidates is reported. Thiophosphorylation of alkylamines was performed using SPCl(3) in aqueous reaction media, and the resulting thiophosphoramidate-S-anions were S-alkylated with soft electrophiles. Ranges of amines and electrophiles were explored.
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ورودعنوان ژورنال:
- Chemical communications
دوره 47 21 شماره
صفحات -
تاریخ انتشار 2011